Abstract
Glioblastoma (GBM) is the most common malignant tumour of the central nervous system. Despite recent advances in multimodal GBM therapy incorporating surgery, radiotherapy, systemic therapy (chemotherapy, targeted therapy), and supportive care, the overall survival (OS) remains poor, and long-term survival is rare. Currently, the primary obstacles hindering the effectiveness of GBM treatment are still the blood-brain barrier and tumor heterogeneity. In light of its substantial advantages over conventional therapies, such as strong penetrative ability and minimal side effects, low-frequency magnetic fields (LF-MFs) therapy has gradually caught the attention of scientists. In this review, we shed the light on the current status of applying LF-MFs in the treatment of GBM. We specifically emphasize our current understanding of the mechanisms by which LF-MFs mediate anticancer effects and the challenges faced by LF-MFs in treating GBM cells. Furthermore, we discuss the prospective applications of magnetic field therapy in the future treatment of GBM. Key scientific concepts of review: The review explores the current progress on the use of LF-MFs in the treatment of GBM with a special focus on the potential underlying mechanisms of LF-MFs in anticancer effects. Additionally, we also discussed the complex magnetic field features and biological characteristics related to magnetic bioeffects. Finally, we proposed a promising magnetic field treatment strategy for future applications in GBM therapy.
Overview
- The study focuses on the use of low-frequency magnetic fields (LF-MFs) in the treatment of glioblastoma (GBM), the most common malignant tumor of the central nervous system. The hypothesis being tested is whether LF-MFs therapy can improve the effectiveness of GBM treatment by overcoming the primary obstacles of blood-brain barrier and tumor heterogeneity. The methodology used for the experiment includes a review of existing literature on the use of LF-MFs in GBM treatment, with a focus on the potential underlying mechanisms of LF-MFs in anticancer effects. The primary objective of the study is to provide a comprehensive understanding of the current progress on the use of LF-MFs in GBM treatment and to propose a promising magnetic field treatment strategy for future applications.
Comparative Analysis & Findings
- The study compares the outcomes observed under different experimental conditions or interventions related to LF-MFs therapy in GBM treatment. The results show that LF-MFs therapy has several advantages over conventional therapies, such as strong penetrative ability and minimal side effects. However, the study also identifies challenges faced by LF-MFs in treating GBM cells, including the complex magnetic field features and biological characteristics related to magnetic bioeffects. The key findings of the study suggest that LF-MFs therapy has the potential to improve the effectiveness of GBM treatment by overcoming the primary obstacles of blood-brain barrier and tumor heterogeneity, but further research is needed to fully understand the mechanisms underlying these effects and to develop more effective magnetic field treatment strategies.
Implications and Future Directions
- The study's findings have significant implications for the field of research and clinical practice in GBM treatment. The study highlights the potential of LF-MFs therapy to improve the effectiveness of GBM treatment by overcoming the primary obstacles of blood-brain barrier and tumor heterogeneity. However, the study also identifies limitations and challenges that need to be addressed in future research, such as the complex magnetic field features and biological characteristics related to magnetic bioeffects. The study suggests possible future research directions that could build on the results of the study, explore unresolved questions, or utilize novel approaches, such as developing more effective magnetic field treatment strategies or combining LF-MFs therapy with other GBM treatment modalities.