Innovative ultrasound assisted synthesis of sponge like cerium dioxide nanostructure using Rosa Damascena extract and its efficient performance for cancer therapy.

in Scientific reports by Mahnaz Amiri, Sahar Zinatloo-Ajabshir, Meysam Ahmadi-Zeidabadi, Fariborz Sharifianjazi

TLDR

  • This study uses a natural capping agent, Rosa Damascena extract, to synthesize cerium dioxide nanostructures with improved cytotoxic effects on cancer cell lines.

Abstract

In this work, cerium dioxide nanostructures were synthesized in an easy sonochemical way. CeOnanoparticles have received much attention in nanotechnology. CeONPs, exhibit biomimetic properties depending on their size, ratio of valency on their surface, and the ambient physico-chemical properties. Nanomedicine has emerged as a promising avenue for targeted cancer therapy, aiming to develop innovative approaches with improved efficacy and reduced side effects. Here, for the production of cerium dioxide nanostructures, a new and natural capping agent called Rosa Damascena extract was utilized, as well as ceric ammonium nitrate as a metal precursor. The results of the characterization of the oxide sample fabricated in the presence of Rosa Damascena extract demonstrated that nanostructures with a sponge-like morphology, which have a pure cubic crystal phase, were formed. The cytotoxicity effect of CeONPs on glioblastoma and neuroblastoma cell lines (T98, SHSY5Y) was studied using the MTT test; cerium oxide nanoparticles exhibited cytotoxicity effects on T98 and SHSY5Y cell lines, compared to the control. The improved cytotoxic effects can be due to the plant secondary metabolites involved in the green synthesis of NPs. Consequently, synthesized CeONPs have revealed an acceptable inhibitory impact upon cancer cell lines.

Overview

  • The study reports the sonochemical synthesis of cerium dioxide nanostructures using a new natural capping agent, Rosa Damascena extract, and ceric ammonium nitrate as a metal precursor.
  • The focus of the study is to investigate the cytotoxic effects of cerium oxide nanoparticles (CeONPs) on glioblastoma and neuroblastoma cell lines and to explore the potential of green synthesis in improving the efficacy of cancer treatment.
  • The primary objective of the study is to develop a novel and efficient approach for synthesizing CeONPs with improved cytotoxic effects on cancer cell lines while minimizing the use of toxic chemicals.

Comparative Analysis & Findings

  • The study found that the CeONPs synthesized using Rosa Damascena extract exhibited a sponge-like morphology with a pure cubic crystal phase.
  • The results of the cytotoxicity test using the MTT assay showed that CeONPs exhibited cytotoxic effects on T98 and SHSY5Y cell lines compared to the control.
  • The improved cytotoxic effects of CeONPs can be attributed to the plant secondary metabolites involved in the green synthesis of NPs.

Implications and Future Directions

  • The study demonstrates the potential of green synthesis as a novel approach for synthesizing CeONPs with improved cytotoxic effects on cancer cell lines.
  • Further studies are needed to explore the optimal conditions for synthesizing CeONPs with optimal morphology and cytotoxic effects.
  • The findings of this study have implications for the development of novel cancer therapies with improved efficacy and reduced side effects.
Read Full Article