Pharmaceutical 3D Printing Technology Integrating Nanomaterials and Nanodevices for Precision Neurological Therapies.

in Pharmaceutics by Jurga Bernatoniene, Mindaugas Plieskis, Kestutis Petrikonis

TLDR

  • This study explores the transformative potential of 3D printing and nanotechnology in precision medicine for neurological diseases, highlighting the need for further research to overcome existing challenges.

Abstract

Pharmaceutical 3D printing, combined with nanomaterials and nanodevices, presents a transformative approach to precision medicine for treating neurological diseases. This technology enables the creation of tailored dosage forms with controlled release profiles, enhancing drug delivery across the blood-brain barrier (BBB). The integration of nanoparticles, such as poly lactic-co-glycolic acid (PLGA), chitosan, and metallic nanomaterials, into 3D-printed scaffolds improves treatment efficacy by providing targeted and prolonged drug release. Recent advances have demonstrated the potential of these systems in treating conditions like Parkinson's disease, epilepsy, and brain tumors. Moreover, 3D printing allows for multi-drug combinations and personalized formulations that adapt to individual patient needs. Novel drug delivery approaches, including stimuli-responsive systems, on-demand dosing, and theragnostics, provide new possibilities for the real-time monitoring and treatment of neurological disorders. Despite these innovations, challenges remain in terms of scalability, regulatory approval, and long-term safety. The future perspectives of this technology suggest its potential to revolutionize neurological treatments by offering patient-specific therapies, improved drug penetration, and enhanced treatment outcomes. This review discusses the current state, applications, and transformative potential of 3D printing and nanotechnology in neurological treatment, highlighting the need for further research to overcome the existing challenges.

Overview

  • The study focuses on the application of 3D printing, nanomaterials, and nanodevices in precision medicine for neurological diseases.
  • The technology enables the creation of tailored dosage forms with controlled release profiles, enhancing drug delivery across the blood-brain barrier.
  • The study aims to review the current state, applications, and transformative potential of this technology in neurological treatment, highlighting the need for further research to overcome existing challenges.

Comparative Analysis & Findings

  • The integration of nanoparticles into 3D-printed scaffolds improves treatment efficacy by providing targeted and prolonged drug release.
  • Recent advances have demonstrated the potential of these systems in treating conditions like Parkinson's disease, epilepsy, and brain tumors.
  • 3D printing allows for multi-drug combinations and personalized formulations that adapt to individual patient needs.

Implications and Future Directions

  • The future perspectives of this technology suggest its potential to revolutionize neurological treatments by offering patient-specific therapies, improved drug penetration, and enhanced treatment outcomes.
  • Challenges remain in terms of scalability, regulatory approval, and long-term safety, requiring further research to overcome these limitations.
  • The development of novel drug delivery approaches, including stimuli-responsive systems, on-demand dosing, and theragnostics, provides new possibilities for real-time monitoring and treatment of neurological disorders.
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