A Radiologist's Guide to IDH-Wildtype Glioblastoma for Efficient Communication With Clinicians: Part II-Essential Information on Post-Treatment Imaging.

in Korean journal of radiology by Philipp Vollmuth, Philipp Karschnia, Felix Sahm, Yae Won Park, Sung Soo Ahn, Rajan Jain

TLDR

  • A comprehensive review of the challenges in differentiating treatment-related changes from true tumor progression in post-treatment imaging of patients with isocitrate dehydrogenase-wildtype glioblastoma.

Abstract

Owing to recent advancements in various postoperative treatment modalities, such as radiation, chemotherapy, antiangiogenic treatment, and immunotherapy, the radiological and clinical assessment of patients with isocitrate dehydrogenase-wildtype glioblastoma using post-treatment imaging has become increasingly challenging. This review highlights the challenges in differentiating treatment-related changes such as pseudoprogression, radiation necrosis, and pseudoresponse from true tumor progression and aims to serve as a guideline for efficient communication with clinicians for optimal management of patients with post-treatment imaging.

Overview

  • The study focuses on the challenges in differentiating treatment-related changes in post-treatment imaging of patients with isocitrate dehydrogenase-wildtype glioblastoma.
  • The study aims to provide a guideline for efficient communication between radiologists and clinicians for optimal patient management.
  • The study highlights the importance of accurate radiological assessment in differentiating treatment-related changes from true tumor progression.

Comparative Analysis & Findings

  • The study discusses the challenges in differentiating treatment-related changes such as pseudoprogression, radiation necrosis, and pseudoresponse from true tumor progression.
  • The study highlights the importance of considering patient-specific factors, such as treatment regimen and clinical history, in the interpretation of post-treatment imaging.
  • The study emphasizes the need for a multidisciplinary approach, involving radiologists, clinicians, and pathologists, to ensure accurate diagnosis and optimal patient management.

Implications and Future Directions

  • The study highlights the need for further research into the development of imaging biomarkers that can accurately differentiate treatment-related changes from true tumor progression.
  • The study suggests that advanced imaging techniques, such as magnetic resonance imaging and diffusion-tensor imaging, may be useful in differentiating treatment-related changes from true tumor progression.
  • The study emphasizes the importance of accurate radiological assessment in guiding treatment decisions and optimizing patient outcomes.
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