Abstract
Glioblastoma (GBM) is a relatively rare but highly aggressive form of brain cancer characterized by rapid growth, invasiveness, and resistance to standard therapies. Despite significant progress in understanding its molecular and cellular mechanisms, GBM remains one of the most challenging cancers to treat due to its high heterogeneity and complex tumor microenvironment. To address these obstacles, researchers have employed a range of models, including in vitro cell cultures and in vivo animal models, but these often fail to replicate the complexity of GBM. As a result, there has been a growing focus on refining these models by incorporating human-origin cells, along with advanced genetic techniques and stem cell-based bioengineering approaches. In this context, a variety of GBM models based on brain organoids were developed and confirmed to be clinically relevant and are contributing to the advancement of GBM research at the preclinical level. This review explores the preparation and use of brain organoid-based models to deepen our understanding of GBM biology and to explore novel therapeutic approaches. These innovative models hold significant promise for improving our ability to study this deadly cancer and for advancing the development of more effective treatments.
Overview
- The study focuses on the development of brain organoid-based models to understand the biology of Glioblastoma (GBM) and explore novel therapeutic approaches.
- The researchers aim to refine existing models by incorporating human-origin cells and advanced genetic techniques to better replicate the complexity of GBM.
- The study explores the preparation and use of brain organoid-based models to deepen our understanding of GBM biology and to explore novel therapeutic approaches.
Comparative Analysis & Findings
- Brain organoid-based models were developed and confirmed to be clinically relevant and are contributing to the advancement of GBM research at the preclinical level.
- These models hold significant promise for improving our ability to study this deadly cancer and for advancing the development of more effective treatments.
- The incorporation of human-origin cells and advanced genetic techniques into brain organoid-based models has improved their predictive value and ability to replicate the complexity of GBM.
Implications and Future Directions
- The development of brain organoid-based models has significant implications for the advancement of GBM research and the development of more effective treatments.
- Future studies can build on these models to explore novel therapeutic approaches and to better understand the biology of GBM, leading to improved patient outcomes.
- The use of brain organoid-based models can also facilitate the development of personalized medicine approaches for GBM patients, taking into account the complex tumor microenvironment and individual patient characteristics.