Abstract
High-grade gliomas are the most common and most lethal primary cancers of the central nervous system. Glioma patients with initial symptoms of cerebral hemorrhage are prone to clinical misdiagnosis and delayed diagnosis. This paper reports the clinical data of a 40-year-old man with glioma who initially presented with cerebral hemorrhage. Cerebral computed tomography (CT) revealed left parietal cerebral hemorrhage, while contrast-enhanced magnetic resonance imaging (MRI) revealed abnormal enhancement of the left frontoparietal junction, indicating internal bleeding of metastatic tumor. Pathological examination confirmed a high-grade glioma, with immunohistochemistry indicating positive glial fibrillary acidic protein (GFAP) and 40% Ki-67 positive labeling. Consequently, the patient received a final diagnosis of glioma (WHO grade IV). We report an interesting case in which glioma initially presented with cerebral hemorrhage. Therefore, gliomas should be considered as a possible cause of cerebral hemorrhage in patients without risk factors for hemorrhage.
Overview
- The study presents a case of a 40-year-old man with glioma who initially presented with cerebral hemorrhage, highlighting the importance of considering glioma as a possible cause of cerebral hemorrhage in patients without risk factors.
- The study aims to report the clinical data of the patient, including the diagnosis, treatment, and outcome, to raise awareness about the potential presentation of glioma with cerebral hemorrhage.
- The study suggests that glioma should be considered as a possible cause of cerebral hemorrhage in patients without risk factors, emphasizing the need for further research and accurate diagnoses.
Comparative Analysis & Findings
- The patient's cerebral CT revealed left parietal cerebral hemorrhage, while contrast-enhanced MRI revealed abnormal enhancement of the left frontoparietal junction, indicating internal bleeding of metastatic tumor.
- Pathological examination confirmed a high-grade glioma, with immunohistochemistry indicating positive glial fibrillary acidic protein (GFAP) and 40% Ki-67 positive labeling.
- The diagnosis was WHO grade IV glioma, which is the most common and most lethal primary cancer of the central nervous system.
Implications and Future Directions
- The study highlights the need for accurate diagnoses and awareness about the potential presentation of glioma with cerebral hemorrhage, especially in patients without risk factors.
- Future research should focus on developing more effective diagnostic methods and treatments for glioma, as well as investigating the underlying causes of glioma-related cerebral hemorrhage.
- Clinicians should consider glioma as a possible cause of cerebral hemorrhage in patients without risk factors and conduct further investigations to rule out other potential causes.