The Dual Function of Autophagy in Doxorubicin-induced Cardiotoxicity: Mechanism and Natural products.

in Seminars in cancer biology by Nannan Tan, Hanwen Luo, Weili Li, Guanjing Ling, Yan Wei, Wei Wang, Yong Wang

TLDR

  • This review summarizes the pathology of autophagy in DOX-induced cardiotoxicity and natural products that can be used as a therapeutic strategy to treat DIC, highlighting the potential benefits of autophagy intervention and natural product therapy.

Abstract

Doxorubicin (DOX) is an anthracycline antitumor drug discovered in 1969, which can care for leukemia, breast cancer, lymphoma, and sarcoma. However, cardiotoxicity induced by DOX seriously limits its clinical value. The etiopathogenesis and therapeutic strategies are not unified. Autophagy is a critical mechanism in the progression of DOX-induced cardiotoxicity (DIC), autophagy intervention is a potential therapeutic strategy for DIC. Natural product has been considered as a complementary and alternative approach to treat cardiovascular disease. In this review, we summarize the pathology of autophagy in DIC and the natural products for DIC therapy.

Overview

  • The study focuses on the effects of Doxorubicin (DOX), an anthracycline antitumor drug, on cardiotoxicity, and explores potential therapeutic strategies for DOX-induced cardiotoxicity (DIC).
  • The study aims to summarize the current understanding of the role of autophagy in the progression of DIC and natural products that can be used to treat DIC.
  • The primary objective is to provide a comprehensive review of the pathology of autophagy in DIC and the natural products that can be used as a therapeutic strategy for DIC.

Comparative Analysis & Findings

  • The study highlights the critical role of autophagy in the progression of DIC, and autophagy intervention is a potential therapeutic strategy for DIC.
  • The review summarizes the current understanding of the pathology of autophagy in DIC and the natural products that can be used to treat DIC.
  • The study emphasizes the need for further research on natural products as a therapeutic strategy for DIC, and the potential benefits of combining natural products with existing treatments.

Implications and Future Directions

  • The study's findings suggest that autophagy inhibition or stimulation by natural products may be a potential therapeutic approach for DIC.
  • Future research directions include investigating the mechanisms of natural products in autophagy regulation and exploring the potential combination of natural products with existing treatments for DIC.
  • The study highlights the need for further studies to determine the optimal dosage and combination of natural products for treating DIC, as well as their potential side effects.
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