Abstract
Oxidative stress refers to the imbalance between the production of reactive oxygen species (ROS) and the endogenous antioxidant defense system. Its involvement in cell senescence, apoptosis, and series diseases has been demonstrated. Advances in carcinogenic research have revealed oxidative stress as a pivotal pathophysiological pathway in tumorigenesis and to be involved in lung cancer, glioma, hepatocellular carcinoma, leukemia, and so on. This review combs the effects of oxidative stress on tumorigenesis on each phase and cell fate determination, and three features are discussed. Oxidative stress takes part in the processes ranging from tumorigenesis to tumor death via series pathways and processes like mitochondrial stress, endoplasmic reticulum stress, and ferroptosis. It can affect cell fate by engaging in the complex relationships between senescence, death, and cancer. The influence of oxidative stress on tumorigenesis and progression is a multi-stage interlaced process that includes two aspects of promotion and inhibition, with mitochondria as the core of regulation. A deeper and more comprehensive understanding of the effects of oxidative stress on tumorigenesis is conducive to exploring more tumor therapies.
Overview
- The study focuses on the role of oxidative stress in tumorigenesis and its effects on cell fate determination. The hypothesis being tested is that oxidative stress plays a crucial role in tumorigenesis and cancer progression through various pathways and processes. The methodology used for the experiment includes a review of existing literature on the effects of oxidative stress on tumorigenesis, including studies on cell fate determination, mitochondrial stress, endoplasmic reticulum stress, and ferroptosis. The primary objective of the study is to provide a comprehensive understanding of the effects of oxidative stress on tumorigenesis and its impact on cell fate determination.
Comparative Analysis & Findings
- The study compares the outcomes observed under different experimental conditions or interventions related to oxidative stress and its effects on tumorigenesis. The results show that oxidative stress plays a multi-stage interlaced process that includes both promotion and inhibition of tumorigenesis and progression. The study identifies mitochondria as the core of regulation for this process. The key findings of the study support the hypothesis that oxidative stress plays a crucial role in tumorigenesis and cancer progression through various pathways and processes.
Implications and Future Directions
- The study's findings have significant implications for the field of research and clinical practice, as a deeper and more comprehensive understanding of the effects of oxidative stress on tumorigenesis is conducive to exploring more tumor therapies. The study identifies several limitations that need to be addressed in future research, including the need for more experimental studies to validate the findings and the need to investigate the role of oxidative stress in specific types of cancer. Possible future research directions include exploring the use of antioxidants as tumor therapies and investigating the role of oxidative stress in the development of drug resistance in cancer.