Glucose Disorders in Patients with Pheochromocytoma/Paraganglioma: Profile and influence effects in a large cohort with 705 patients.

in Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists by Wenqian Zhang, Jie Yu, Yinghan Chen, Yue Zhou, Yunying Cui, Tianyi Li, Yu Wang, Weidong Ren, Anli Tong, Yuxiu Li

TLDR

  • The study found that catecholamines, which are chemicals produced by the body, play a pivotal role in metabolic processes. Patients with PPGL, a rare tumor, often have glucose metabolic disorders. The study found that catecholamines are linked to these disorders and that monitoring blood glucose levels is crucial for patients with PPGL. Almost 70% of the patients in the study had disturbances in glucose metabolism, with over one-third diagnosed with diabetes. The study highlights the importance of understanding the relationship between catecholamines and glucose metabolic disorders in PPGL and suggests that further research is needed to identify potential therapeutic targets for managing these disorders.

Abstract

Some patients with Pheochromocytoma and Paraganglioma (PPGL) suffer from glucose metabolic disorders. The aim was to investigate the relationship between glucose metabolic disorders and catecholamine levels in 705 patients with PPGL. A retrospective analysis was conducted on the clinical data of 705 patients diagnosed with PPGL at Peking Union Medical College Hospital from 2018 to 2023. Bar chart was utilized to depict the manifestations of glycemic disorder across different genders, age groups, BMI, and catecholamine secretion types. Comparison of characteristics between patients with PPGL who had glycemic disorders and those who did not was conducted. Binary logistic regression analysis coupled with Receiver Operating Characteristic (ROC) curves was utilized to predict the occurrence of glycemic disorders. Of 705 patients, 492 patients were diagnosed with glucose abnormalities, while the remaining 213 had normal glucose metabolism. Compared to the normal glycemic group, the glycemic disorder group had significantly higher levels of HOMA-IR and TyG index, as well as higher HDL, LDL, and TC. Univariate logistic regression identified age, norepinephrine, and epinephrine as independent risk factors for the occurrence of glucose metabolism disorders.After adjusting for confounding variables, age at diagnosis and norepinephrine levels both remained significant, confirming their roles as key risk factors. Almost 70% of the patients manifested disturbances in glucose metabolism, with over one-third diagnosed with diabetes. These findings underscore the pivotal role catecholamines play in metabolic processes and emphasize the imperative need for close monitoring of blood glucose levels in patients with PPGL.

Overview

  • The study investigates the relationship between glucose metabolic disorders and catecholamine levels in 705 patients with Pheochromocytoma and Paraganglioma (PPGL).
  • A retrospective analysis was conducted on the clinical data of 705 patients diagnosed with PPGL at Peking Union Medical College Hospital from 2018 to 2023. Bar chart was utilized to depict the manifestations of glycemic disorder across different genders, age groups, BMI, and catecholamine secretion types. Comparison of characteristics between patients with PPGL who had glycemic disorders and those who did not was conducted. Binary logistic regression analysis coupled with Receiver Operating Characteristic (ROC) curves was utilized to predict the occurrence of glycemic disorders. Of 705 patients, 492 patients were diagnosed with glucose abnormalities, while the remaining 213 had normal glucose metabolism. Compared to the normal glycemic group, the glycemic disorder group had significantly higher levels of HOMA-IR and TyG index, as well as higher HDL, LDL, and TC. Univariate logistic regression identified age, norepinephrine, and epinephrine as independent risk factors for the occurrence of glucose metabolism disorders.After adjusting for confounding variables, age at diagnosis and norepinephrine levels both remained significant, confirming their roles as key risk factors. Almost 70% of the patients manifested disturbances in glucose metabolism, with over one-third diagnosed with diabetes. These findings underscore the pivotal role catecholamines play in metabolic processes and emphasize the imperative need for close monitoring of blood glucose levels in patients with PPGL.

Comparative Analysis & Findings

  • The study found that compared to the normal glycemic group, the glycemic disorder group had significantly higher levels of HOMA-IR and TyG index, as well as higher HDL, LDL, and TC. Univariate logistic regression identified age, norepinephrine, and epinephrine as independent risk factors for the occurrence of glucose metabolism disorders.After adjusting for confounding variables, age at diagnosis and norepinephrine levels both remained significant, confirming their roles as key risk factors. Almost 70% of the patients manifested disturbances in glucose metabolism, with over one-third diagnosed with diabetes. These findings underscore the pivotal role catecholamines play in metabolic processes and emphasize the imperative need for close monitoring of blood glucose levels in patients with PPGL.

Implications and Future Directions

  • The study highlights the importance of monitoring catecholamine levels in patients with PPGL and the need for close monitoring of blood glucose levels. Future research should focus on identifying the underlying mechanisms of the relationship between catecholamines and glucose metabolic disorders in PPGL. Additionally, further studies should investigate the role of catecholamines in the development and progression of PPGL, as well as the potential therapeutic targets for managing glucose metabolic disorders in PPGL.
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