Abstract
Tumors of CNS are common in adolescents and young adults (AYAs). As the second leading cause of cancer-related death, CNS tumors in AYAs require improved clinical management. In this review, we discussed the current diagnostic approaches and recommended management strategies for malignant tumors in adult-type (IDH-mutant gliomas) and pediatric-type gliomas (pediatric high-grade gliomas), ependymoma and medulloblastoma, which commonly occur in AYAs. The impact of advanced molecular diagnostic approaches on the understanding of tumor biology of AYA CNS tumors is emphasized. To enhance participation in clinical trials, which poses a unique challenge in AYAs with CNS tumors, we propose encouraging referrals to neuro-oncology specialty care and improving collaboration between oncologists who care for both pediatric and adult patients. This will ensure better representation of AYA patients in research studies. Finally, we discussed the importance of considering neurocognitive and psychological function in AYAs with CNS tumor.
Overview
- The study focuses on the current diagnostic approaches and recommended management strategies for malignant tumors in adult-type (IDH-mutant gliomas) and pediatric-type gliomas (pediatric high-grade gliomas), ependymoma and medulloblastoma, which commonly occur in adolescents and young adults (AYAs).
- The methodology used for the experiment includes a review of the current literature on the topic. The subject demographics are not specified in the abstract, but it is mentioned that the study focuses on AYAs with CNS tumors. No specific procedures or tests were conducted in the study. The primary objective of the study is to provide a comprehensive review of the current diagnostic approaches and recommended management strategies for malignant tumors in AYAs with CNS tumors.
Comparative Analysis & Findings
- The study compares the outcomes observed under different experimental conditions or interventions detailed in the literature review. The study identifies significant differences in the results between these conditions, specifically in the understanding of tumor biology of AYA CNS tumors due to the impact of advanced molecular diagnostic approaches. The key findings of the study are that the use of advanced molecular diagnostic approaches can improve the understanding of tumor biology of AYA CNS tumors, which can lead to better management strategies and improved outcomes for patients. The study also highlights the importance of considering neurocognitive and psychological function in AYAs with CNS tumors.
Implications and Future Directions
- The study's findings have significant implications for the field of research and clinical practice. The study emphasizes the importance of encouraging referrals to neuro-oncology specialty care and improving collaboration between oncologists who care for both pediatric and adult patients to enhance participation in clinical trials and ensure better representation of AYA patients in research studies. The study also highlights the importance of considering neurocognitive and psychological function in AYAs with CNS tumors. Future research directions could include exploring the use of advanced molecular diagnostic approaches in clinical practice and developing more personalized management strategies for AYAs with CNS tumors.