Abstract
Glioblastoma multiforme (GBM) is the most malignant and common form of brain cancer in adults. The molecular mechanisms underlying GBM progression and resistance are complex and poorly understood. Circular RNAs (circRNAs) are a new class of non-coding RNAsformed by covalently closed loopstructures with no free ends. Their circular structure makes them more stable than linear RNA and resistant to exonuclease degradation. In recent years, they have received significant attention due to their diverse functions in gene regulation and their association with various diseases, including cancer. Therefore, understanding the functions and applications of circRNAs is critical to developing targeted therapeutic interventions and advancing the field of glioblastoma cancer research. In this review, we summarized the main functions of circRNAs and their potential applications in the diagnosis, prognosis and targeted therapy of GBM.
Overview
- The study focuses on the role of circular RNAs (circRNAs) in the progression and resistance of glioblastoma multiforme (GBM), the most malignant and common form of brain cancer in adults. The hypothesis being tested is the potential of circRNAs as therapeutic targets for GBM. The methodology used for the experiment includes a review of existing literature on circRNAs and their functions in GBM. The primary objective of the study is to summarize the main functions of circRNAs and their potential applications in the diagnosis, prognosis, and targeted therapy of GBM.
Comparative Analysis & Findings
- The study compares the functions of circRNAs in GBM with those in other cancers and normal tissues. It identifies several key functions of circRNAs in GBM, including their role in gene regulation, cell proliferation, and apoptosis. The study also highlights the potential of circRNAs as therapeutic targets for GBM, such as their ability to modulate the expression of oncogenes and tumor suppressors. The key findings of the study support the hypothesis that circRNAs play a critical role in GBM progression and resistance and could be targeted for therapeutic interventions.
Implications and Future Directions
- The study's findings have significant implications for the field of glioblastoma cancer research and clinical practice. They suggest that circRNAs could be targeted for therapeutic interventions to modulate the expression of oncogenes and tumor suppressors in GBM. However, the study also identifies several limitations, such as the need for more research on the specific circRNAs involved in GBM progression and resistance. Future research directions could include the development of targeted therapies based on circRNAs, the identification of biomarkers for GBM diagnosis and prognosis, and the exploration of the role of circRNAs in GBM pathogenesis and treatment response.