Traumatic brain injury increasing risk of meningioma? From the genetic evidence.

in World neurosurgery by Chunming He, Tao Long, Huaiyu Zhou, Chuan Zeng, Peng Xiong, Xinyu Qiu, Haimin Song

TLDR

  • This study used genetic evidence to investigate whether TBI increases the risk of meningioma. The study found no evidence to support this claim.

Abstract

Numerous studies have demonstrated a strong association between traumatic brain injury (TBI) and an increased risk of meningioma. However, this correlation remains controversial. This study utilized mendelian randomization to explore this relationship from perspective of genetic evidence. We employed six traumatic brain injury genome-wide association study (GWAS) datasets from the IEU GWAS database. Summary statistics for meningioma were sourced from the FinnGen R10 database. We assessed heterogeneity and horizontal pleiotropy within the analyzed data. The primary method was inverse variance weighting (IVW) to investigate the causal relationship between TBI and meningioma, excluding cases with horizontal pleiotropy. Four supplementary analysis methods were also used, with abnormal results excluded based on leave-one-out sensitivity analysis. All six Mendelian randomization analyses indicated no causal relationship between TBI and meningiomas (Focal brain injury IVW p-value = 0.98; Diffuse brain injury IVW p-value = 0.41; TBI without concussion IVW p-value = 0.45; Intracranial trauma IVW p-value = 0.34; Traumatic subdural hemorrhage IVW p-value = 0.80; Traumatic subarachnoid hemorrhage IVW p-value = 0.92). The mendelian randomization study revealed that traumatic brain injury does not increase the risk of meningioma based on genetic evidence.

Overview

  • The study aimed to investigate the causal relationship between traumatic brain injury (TBI) and meningioma using mendelian randomization.
  • The methodology involved using six TBI genome-wide association study (GWAS) datasets from the IEU GWAS database and sourcing summary statistics for meningioma from the FinnGen R10 database.
  • The primary objective was to assess heterogeneity and horizontal pleiotropy within the analyzed data and investigate the causal relationship between TBI and meningioma using inverse variance weighting (IVW) to exclude cases with horizontal pleiotropy.

Comparative Analysis & Findings

  • The study found no causal relationship between TBI and meningioma based on genetic evidence.
  • The IVW analysis for focal brain injury showed a p-value of 0.98, while the IVW analysis for diffuse brain injury showed a p-value of 0.41.
  • The IVW analysis for TBI without concussion showed a p-value of 0.45, while the IVW analysis for intracranial trauma showed a p-value of 0.34.
  • The IVW analysis for traumatic subdural hemorrhage showed a p-value of 0.80, while the IVW analysis for traumatic subarachnoid hemorrhage showed a p-value of 0.92.

Implications and Future Directions

  • The study's findings suggest that TBI does not increase the risk of meningioma based on genetic evidence.
  • The study highlights the importance of considering genetic evidence when investigating the relationship between TBI and meningioma.
  • Future research should explore other potential confounding factors that may influence this relationship.
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