Pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma: additional evidence to support they are a single disease with variation in the histologic spectrum.

in Virchows Archiv : an international journal of pathology by Huan-Ge Li, Xiang-Nan Jiang, Tian Xue, Bei-Bei Xin, Lian Chen, Gui-Xin Li, Qian Wang, Qin-Qin Hou, Xu Cai, Xiao-Yan Zhou, Xiao-Qiu Li

TLDR

  • The study found that PTFL and PNMZL have similar or overlapping clinical, pathologic, and genetic features. PTFL and PNMZL are likely to represent two different histologic patterns of the same disease. MTT cases showed a composite form of enlarged follicles and interfollicular lymphocytic proliferation producing a progressively transformed germinal center (PTGC) pattern, and focal follicles with a PTGC-like pattern were observed in PTFL cases. Genetically, the most frequently mutated genes were TNFRSF14 (in 3 PTFLs and 2 MTTs), MAP2K1 (in 2 PTFLs, 1 PNMZL and 1 MTT), and IRF8 (in 2 MTTs and 1 PNMZL).
  • The study found that PTFL and PNMZL have similar or overlapping clinical, pathologic, and genetic features. PTFL and PNMZL are likely to represent two different histologic patterns of the same disease. MTT cases showed a composite form of enlarged follicles and interfollicular lymphocytic proliferation producing a progressively transformed germinal center (PTGC) pattern, and focal follicles with a PTGC-like pattern were observed in PTFL cases. Genetically, the most frequently mutated genes were TNFRSF14 (in 3 PTFLs and 2 MTTs), MAP2K1 (in 2 PTFLs, 1 PNMZL and 1 MTT), and IRF8 (in 2 MTTs and 1 PNMZL).

Abstract

Pediatric-type follicular lymphoma (PTFL) and pediatric nodal marginal zone lymphoma (PNMZL) are two rare indolent B-cell lymphomas with overlapping features. Recently, cases showing hybridizing features of PTFL and PNMZL have been reported. Herein, we retrospectively analyzed the clinicopathologic features of 59 patients, including 39 with PTFL, 5 with PNMZL, and 15 with mixed-type tumors (MTT). And next-generation sequencing analysis was performed on 3 PTFL, 2 PNMZL, and 2 MTT cases. In addition, previously published mutational data of 96 PTFLs, 25 PNMZLs, and 46 MTTs were also analyzed. There were 52 male and 7 female patients, with a median age of 17 years. Most patients (96.6%) had lymph node involvement in the head and neck region and were diagnosed with stage I disease. Among the 50 patients (85%) with telephone follow-up, 44 (88%) adopted a watch-and-wait strategy after surgical resection of the lesions. Only one PTFL patient experienced a relapse 6 months after diagnosis. Microscopically, not only the MTT cases showed a composite form of enlarged follicles and interfollicular lymphocytic proliferation producing a progressively transformed germinal center (PTGC) pattern, but also focal follicles with a PTGC-like pattern were observed in PTFL cases. Genetically, the most frequently mutated genes were TNFRSF14 (in 3 PTFLs and 2 MTTs), MAP2K1 (in 2 PTFLs, 1 PNMZL and 1 MTT), and IRF8 (in 2 MTTs and 1 PNMZL). Based on the similar or overlapping clinical, pathologic, and genetic features, PTFL and PNMZL are likely to represent two different histologic patterns of the same disease.

Overview

  • The study aims to analyze the clinicopathologic features and genetic mutations of pediatric-type follicular lymphoma (PTFL), pediatric nodal marginal zone lymphoma (PNMZL), and mixed-type tumors (MTT).
  • The study retrospectively analyzed the clinicopathologic features of 59 patients, including 39 with PTFL, 5 with PNMZL, and 15 with MTT. Next-generation sequencing analysis was performed on 3 PTFL, 2 PNMZL, and 2 MTT cases. Previously published mutational data of 96 PTFLs, 25 PNMZLs, and 46 MTTs were also analyzed. There were 52 male and 7 female patients, with a median age of 17 years. Most patients (96.6%) had lymph node involvement in the head and neck region and were diagnosed with stage I disease. Among the 50 patients (85%) with telephone follow-up, 44 (88%) adopted a watch-and-wait strategy after surgical resection of the lesions. Only one PTFL patient experienced a relapse 6 months after diagnosis. Microscopically, not only the MTT cases showed a composite form of enlarged follicles and interfollicular lymphocytic proliferation producing a progressively transformed germinal center (PTGC) pattern, but also focal follicles with a PTGC-like pattern were observed in PTFL cases. Genetically, the most frequently mutated genes were TNFRSF14 (in 3 PTFLs and 2 MTTs), MAP2K1 (in 2 PTFLs, 1 PNMZL and 1 MTT), and IRF8 (in 2 MTTs and 1 PNMZL).
  • The primary objective of the study is to investigate the clinicopathologic features and genetic mutations of PTFL, PNMZL, and MTT to determine if they represent two different histologic patterns of the same disease.

Comparative Analysis & Findings

  • The study found that PTFL and PNMZL have similar or overlapping clinical, pathologic, and genetic features. PTFL and PNMZL are likely to represent two different histologic patterns of the same disease. MTT cases showed a composite form of enlarged follicles and interfollicular lymphocytic proliferation producing a progressively transformed germinal center (PTGC) pattern, and focal follicles with a PTGC-like pattern were observed in PTFL cases. Genetically, the most frequently mutated genes were TNFRSF14 (in 3 PTFLs and 2 MTTs), MAP2K1 (in 2 PTFLs, 1 PNMZL and 1 MTT), and IRF8 (in 2 MTTs and 1 PNMZL).

Implications and Future Directions

  • The study's findings suggest that PTFL and PNMZL may represent two different histologic patterns of the same disease. Further research is needed to determine the clinical and pathologic differences between PTFL and PNMZL. The study's findings also highlight the importance of genetic testing in the diagnosis and management of PTFL and PNMZL. Future research should focus on identifying additional genetic mutations and determining their clinical and pathologic significance. The study's findings also suggest that PTFL and PNMZL may be more closely related than previously thought, and further research is needed to determine the underlying biology of these diseases.