Abstract
Follicular lymphoma is one of the most common non-Hodgkin's lymphomas with an expected survival of more than 20 years for the majority of patients. This impressive outcome has been achieved with the introduction of immunochemotherapy, as first line treatment with remissions lasting over 8 years, followed by other treatment options at first or subsequent relapse. However, certain groups of patients still have a poor prognosis. In recent years the efficacy of chemotherapy regimens has been augmented by new compounds selectively targeting the cell surface, intracellular pathways, and/or the microenvironment. Some of these are beginning to change the therapeutic landscape. This review summarizes prognostic factors in follicular lymphoma in order to identify patients with greatest medical need for these new treatment options and reviews recent data from prospective clinical studies testing new agents in first-line and relapsed follicular lymphoma. Finally, we assess the current role of immunochemotherapy and discuss the requirements for future clinical trials.
Overview
- Follicular lymphoma is a common non-Hodgkin's lymphoma with an expected survival of more than 20 years for the majority of patients. The study aims to identify prognostic factors in follicular lymphoma to identify patients with greatest medical need for new treatment options and review recent data from prospective clinical studies testing new agents in first-line and relapsed follicular lymphoma. The study also assesses the current role of immunochemotherapy and discusses the requirements for future clinical trials.
Comparative Analysis & Findings
- The study compares the outcomes observed under different experimental conditions or interventions detailed in the study. The study identifies certain groups of patients with a poor prognosis. The study also discusses the key findings of the study and how they relate to the initial hypothesis.
Implications and Future Directions
- The study explains the significance of the study's findings and their potential impact on the field of research or clinical practice. The study identifies any limitations of the study that need to be addressed in future research. The study suggests possible future research directions that could build on the results of the study, explore unresolved questions, or utilize novel approaches.