Abstract
With rapid and non-invasive characteristics, the respiratory route of administration has drawn significant attention compared with the limitations of conventional routes. Respiratory delivery can bypass the physiological barrier to achieve local and systemic disease treatment. A scientometric analysis and review were used to analyze how respiratory delivery can contribute to local and systemic therapy. The literature data obtained from the Web of Science Core Collection database showed an increasing worldwide tendency toward respiratory delivery from 1998 to 2020. Keywords analysis suggested that nasal and pulmonary drug delivery are the leading research topics in respiratory delivery. Based on the results of scientometric analysis, the research hotspots mainly included therapy for central nervous systems (CNS) disorders (Parkinson's disease, Alzheimer's disease, depression, glioblastoma, and epilepsy), tracheal and bronchial or lung diseases (chronic obstructive pulmonary disease, asthma, acute lung injury or respiratory distress syndrome, lung cancer, and idiopathic pulmonary fibrosis), and systemic diseases (diabetes and COVID-19). The study of advanced preparations contained nano drug delivery systems of the respiratory route, drug delivery barriers investigation (blood-brain barrier, BBB), and chitosan-based biomaterials for respiratory delivery. These results provided researchers with future research directions related to respiratory delivery.
Overview
- The study focuses on the potential of respiratory delivery for local and systemic therapy. The methodology involves a scientometric analysis of the Web of Science Core Collection database from 1998 to 2020. The study identifies nasal and pulmonary drug delivery as the leading research topics in respiratory delivery. Key research hotspots include therapy for CNS disorders, tracheal and bronchial or lung diseases, and systemic diseases. The study also explores advanced preparations, such as nano drug delivery systems, drug delivery barriers investigation, and chitosan-based biomaterials for respiratory delivery.
Comparative Analysis & Findings
- The study shows an increasing worldwide tendency toward respiratory delivery from 1998 to 2020. The research hotspots identified in the study include therapy for CNS disorders, tracheal and bronchial or lung diseases, and systemic diseases. The study also highlights the potential of advanced preparations, such as nano drug delivery systems, drug delivery barriers investigation, and chitosan-based biomaterials for respiratory delivery.
Implications and Future Directions
- The study's findings suggest that respiratory delivery has significant potential for local and systemic therapy. The study identifies several research hotspots, including therapy for CNS disorders, tracheal and bronchial or lung diseases, and systemic diseases. The study also highlights the potential of advanced preparations, such as nano drug delivery systems, drug delivery barriers investigation, and chitosan-based biomaterials for respiratory delivery. Future research should focus on developing more advanced preparations and exploring new applications of respiratory delivery in various diseases.