Abstract
Intrasinusoidal bone marrow involvement is an infrequent histological pattern observed in a limited number of B and T cell lymphomas. Mantle cell lymphoma is a biologically and prognostically heterogeneous B cell lymphoma that frequently involves the bone marrow, with interstitial, nodular-paratrabecular, or diffuse patterns. Intrasinusoidal bone marrow involvement has been described only anecdotally in this lymphoma. Here, we describe the clinical, histopathological, and molecular features of four patients diagnosed with advanced-stage mantle cell lymphoma, showing intrasinusoidal bone marrow involvement, and other peculiar immunophenotypical features. As similar cases may represent a relevant issue in bone marrow diagnostic histopathology, we also reviewed the literature to discuss differential diagnoses of B and T cell lymphomas with intrasinusoidal bone marrow involvement.
Overview
- Main focus of the study: Description of four patients with advanced-stage mantle cell lymphoma showing intrasinusoidal bone marrow involvement and other peculiar immunophenotypical features.
- Methodology: Clinical, histopathological, and molecular features of the patients were analyzed.
- Primary objective: To describe the clinical, histopathological, and molecular features of patients with advanced-stage mantle cell lymphoma showing intrasinusoidal bone marrow involvement.
Comparative Analysis & Findings
- Four patients with advanced-stage mantle cell lymphoma showed intrasinusoidal bone marrow involvement.
- Review of literature indicates that similar cases may represent a relevant issue in bone marrow diagnostic histopathology.
- Differential diagnoses of B and T cell lymphomas with intrasinusoidal bone marrow involvement were discussed.
Implications and Future Directions
- The study highlights the importance of considering intrasinusoidal bone marrow involvement in the differential diagnosis of B and T cell lymphomas.
- Future studies are needed to further understand the molecular mechanisms underlying intrasinusoidal bone marrow involvement in mantle cell lymphoma.
- Implementation of standardized criteria for diagnosing intrasinusoidal bone marrow involvement is recommended to ensure accurate diagnosis and treatment.