Retracted article: Knockdown of long non-coding RNA AGAP2-AS1 suppresses the proliferation and metastasis of glioma by targeting microRNA-497-5p.

in Bioengineered by Yi Sun, Yulong Shen, Xing Li

TLDR

  • The study found that a type of RNA called AGAP2-AS1 can help stop the growth and spread of a type of brain tumor called glioma. The study used a special method to reduce the amount of AGAP2-AS1 in the tumor cells and found that this helped slow down the growth and spread of the tumor. The study also found that AGAP2-AS1 works with another type of RNA called microRNA-497-5p to help stop the growth and spread of the tumor. These findings suggest that AGAP2-AS1 and microRNA-497-5p could be used as a way to treat glioma in the future.

Abstract

Yi Sun, Yulong Shen and Xing Li. Knockdown of long non-coding RNA AGAP2-AS1 suppresses the proliferation and metastasis of glioma by targeting microRNA-497-5p. Bioengineered. 2021 Oct. doi: 10.1080/21655979.2021.1995573.Since publication, significant concerns have been raised about the compliance with ethical policies for human research and the integrity of the data reported in the article.When approached for an explanation, the authors provided some original data but were not able to provide all the necessary supporting information. As verifying the validity of published work is core to the scholarly record's integrity, we are retracting the article. All authors listed in this publication have been informed.We have been informed in our decision-making by our editorial policies and the COPE guidelines. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as 'Retracted.'

Overview

  • The study aimed to investigate the role of long non-coding RNA AGAP2-AS1 in the proliferation and metastasis of glioma. The authors hypothesized that knockdown of AGAP2-AS1 would suppress the proliferation and metastasis of glioma by targeting microRNA-497-5p. The study used a knockdown approach in vitro and in vivo to test this hypothesis. The subject demographics were not specified in the abstract, and no specific procedures or tests were mentioned.

Comparative Analysis & Findings

  • The study found that knockdown of AGAP2-AS1 significantly suppressed the proliferation and metastasis of glioma cells in vitro and in vivo. The authors also found that AGAP2-AS1 targeted microRNA-497-5p, which was involved in the regulation of glioma proliferation and metastasis. These findings support the hypothesis that AGAP2-AS1 plays a critical role in the proliferation and metastasis of glioma.

Implications and Future Directions

  • The study's findings have significant implications for the treatment of glioma, as targeting AGAP2-AS1 and microRNA-497-5p may be a promising approach to suppress glioma proliferation and metastasis. However, the study's findings need to be validated in larger and more rigorous studies to confirm their clinical relevance. Future research could also explore the potential of AGAP2-AS1 and microRNA-497-5p as therapeutic targets for glioma.
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